What is Depakote DR (Divalproex sodium DR)?
Divalproex sodium affects chemicals in the body that may be involved in causing seizures.Divalproex sodium is used to treat various types of seizure disorders. Divalproex sodium is sometimes used together with other seizure medications.Divalproex sodium may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about Depakote DR (Divalproex sodium DR) ?
In rare cases, divalproex sodium has caused life-threatening liver failure, especially in children younger than 2 years old. Children may be at even greater risk for liver problems if they use more than one seizure medication, if they have a metabolic disorder, or if they have a brain disease causing mental impairment (such as Creutzfeldt-Jacob disease, Huntington disease, multiple sclerosis, or a brain injury or infection). Seek emergency medical attention if the person taking this medicine has nausea, vomiting, stomach pain, or loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These symptoms may be early signs of liver damage. Some of these symptoms may also be early signs of pancreatitis. Divalproex sodium can cause birth defects. Do not use this medication without your doctor's consent if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. You may have thoughts about suicide while taking this medication. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
What should I discuss with my healthcare provider before taking Depakote DR (Divalproex sodium DR) ?
In rare cases, divalproex sodium has caused life-threatening liver failure, especially in children younger than 2 years old. Children of this age may be at even greater risk for liver problems if they use more than one seizure medication, if they have a metabolic disorder, or if they have a brain disease causing mental impairment (such as Creutzfeldt-Jacob disease, Huntington disease, multiple sclerosis, or a brain injury or infection). Divalproex sodium has also caused rare cases of life-threatening pancreatitis (inflammation of the pancreas). Pancreatitis can come on suddenly and symptoms may start even after you have been taking divalproex sodium for several years. Do not take divalproex sodium if you have liver disease or a urea cycle disorder. If you have any of these other conditions, you may need a dose adjustment or special tests to safely take divalproex sodium.a bleeding or blood clotting disorder;a history of head injury, brain disorder, or coma;a family history of a urea cycle disorder;a family history of infant deaths with unknown cause; orHIV or CMV (cytomegalovirus) infection.You may have thoughts about suicide while taking this medication. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed.Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.
How should I take Depakote DR (Divalproex sodium DR) ?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the instructions on your prescription label.Drink plenty of water while you are taking this medication. Your dose may need to be changed if you do not get enough fluids each day. To be sure this medication is not causing harmful effects, your liver function will need to be tested. It is important that you not miss any scheduled visits to your doctor.Do not stop taking the medication even if you feel better. It is important to take divalproex sodium regularly to prevent seizures from recurring. Get your prescription refilled before you run out of medicine completely. Call your doctor promptly if this medicine does not seem to be working as well in preventing your seizures. Do not crush, chew, break, or open a delayed-release or extended-release tablet or capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. You may open the divalproex sodium sprinkle capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule.Carry an ID card or wear a medical alert bracelet stating that you are taking divalproex sodium, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking divalproex sodium. Store divalproex sodium at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include sleepiness or drowsiness, shallow breathing, weak pulse, or loss of consciousness.
What should I avoid while taking Depakote DR (Divalproex sodium DR) ?
Avoid drinking alcohol, which can increase some of the side effects of divalproex sodium. Divalproex sodium can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Divalproex sodium can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
Side effects of Depakote DR (Divalproex sodium DR)
Seek emergency medical attention if the person taking this medicine has nausea, vomiting, stomach pain, or loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These symptoms may be early signs of liver damage. Some of these symptoms may also be early signs of pancreatitis. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: unexplained weakness with vomiting and confusion or fainting;easy bruising or bleeding, blood in your urine;fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;fever, chills, body aches, flu symptoms;urinating less than usual;hallucinations (seeing things that aren't there);extreme drowsiness, lack of coordination; ordouble vision or back-and-forth movements of the eyes.Less serious side effects may include:mild drowsiness or weakness;diarrhea, constipation, upset stomach;depression, anxiety, or other emotional changes;changes in your menstrual periods;enlarged breasts;tremor (shaking);hair loss;weight changes;vision changes; orunusual or unpleasant taste in your mouth.
What other drugs will affect Depakote DR (Divalproex sodium DR) ?
Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety can add to sleepiness caused by divalproex sodium. Tell your doctor if you regularly use any of these medicines, or any other seizure medication.
Before taking divalproex sodium, tell your doctor if you are using any of the following drugs:topiramate (Topamax);tolbutamide (Orinase);a blood thinner such as warfarin (Coumadin);aspirin or acetaminophen (Tylenol);zidovudine (Retrovir);clozapine (Clozaril, FazaClo);diazepam (Valium);meropenem (Merrem);rifampin (Rifadin, Rimactane, Rifater); orethosuximide (Zarontin).
