Menotropin is a hormonally active medication for the treatment of fertility disturbances. Frequently the plural is used as the medication is a mixture of gonadotropins. Menotropins are extracted from the urine of postmenopausal women
When should Menotropins not to be taken? (Contraindications)
This medication is not advisable to pregnant & breastfeeding women. Ovarian cysts or enlarged ovaries (not due to polycystic ovarian syndrome), uncontrolled thyroid and adrenal dysfunction, organic intracranial lesions (e.g. pituitary tumours), abnormal genital bleeding of unknown cause, presence of other causes of infertility other than anovulation (unless they are candidates of in vitro-fertilization), hormone sensitive tumours e.g. breast, uterus, prostate, ovaries or testes. Primary ovarian failure, malformation of sexual organs or fibroid tumours of the uterus incompatible with pregnancy, structural abnormalities such as tubal occlusion (unless super ovulation is to be induced), ovarian dysgenesis, absence of uterus or premature menopause.
What is the dosage of Menotropins?
IM/SC- Female Infertility- Daily dose providing 75-150u FSH. Adjust dose gradually till adequate response. Once reached, stop menotropin and induce ovulation with chorionic gonadotrophin 1-2 days later. In menstruating patients, start treatment within the 1st 7 days of the menstrual cycle; may repeat cycle at least twice more if needed.
How should Menotropins be taken?
It is usually administered as an injection under the skin (subcutaneously) by a health care provider.
What are the warnings and precautions for Menotropins?
- It may cause dizziness. Do not drive a car, operate machinery, or do anything else that could be dangerous until you know how you react to this medication.
- Monitor ovarian activity and measure urinary estrogen at regular intervals, until stimulation occurs.
- Discontinue this treatment and withhold human chorionic gonadotrophin if urinary estrogen levels >540 nmol/24 hours, or if plasma 17 β-estradiol levels >3000 pmol/l, or if there is any sharp rise in values.
- Refrain from sexual intercourse or use barrier contraception methods for at least 4 days and pelvic examinations to be avoided or carried out with care.
- Caution should be exercised in patients with history liver, kidney disease, any allergy, and who are taking other medications.
